Nicotinamide adenine dinucleotide, a coenzyme critical for cellular energy metabolism that declines with age. NAD+ precursors like NMN and NR are studied as longevity interventions.

Mechanistic target of rapamycin, a key nutrient-sensing pathway that regulates cell growth and aging. Inhibiting mTOR (e.g., with rapamycin) has shown lifespan extension in multiple organisms.

A class of drugs that selectively eliminate senescent (aged, dysfunctional) cells to reduce inflammation and improve tissue function.

What is Epigenetic clock?

A biomarker based on DNA methylation patterns that estimates biological age, often more predictive of health outcomes than chronological age.

The period of life spent in good health, free from chronic diseases and disability associated with aging.

An immunosuppressant drug that inhibits the mTOR pathway. Research shows rapamycin may extend lifespan and improve age-related health outcomes in multiple species.

What is Biological age?

A measure of how well or poorly your body is functioning relative to your chronological age, assessed through biomarkers such as DNA methylation, telomere length, and blood panels.

What is Caloric restriction?

A dietary regimen that reduces calorie intake without malnutrition. Caloric restriction is one of the most studied interventions shown to extend lifespan across species.

Protective caps at the ends of chromosomes that shorten with each cell division. Telomere length is associated with aging and age-related diseases.

A state in which cells permanently stop dividing but resist death, accumulating with age and secreting inflammatory factors that damage surrounding tissue.

A second-generation epigenetic clock that predicts time to death and is considered one of the most accurate measures of biological aging.

What is Inflammaging?

Chronic, low-grade inflammation that increases with age and contributes to the development of age-related diseases including cardiovascular disease, diabetes, and neurodegeneration.

The large-scale study of proteins in biological systems. In longevity research, proteomics identifies blood protein signatures that predict biological age and disease risk.

What is Yamanaka factors?

A set of four transcription factors (Oct4, Sox2, Klf4, c-Myc) that can reprogram adult cells to a pluripotent state. Partial reprogramming with Yamanaka factors is being explored to reverse cellular aging.

Nicotinamide mononucleotide, a precursor to NAD+ that is widely studied as a supplement to boost cellular energy and combat age-related decline.

A gene-editing technology that allows precise modifications to DNA. In longevity research, CRISPR is used to study and potentially modify genes associated with aging.

Emergent BioSolutions Partners with British Columbia to Supply NARCAN® Nasal Spray for the Launch of the Expanded BC Take Home Naloxone Program

Emergent BioSolutions has partnered with the B.C. Provincial Health Services Authority (PHSA) to supply NARCAN® Nasal Spray for the province’s Take-Home Naloxone Program (BC THN Program), following an $18 million CAD investment by the B.C. government to enhance access to this critical intervention. This initiative expands upon a successful pilot program initiated in 2024, which distributed 60,000 nasal naloxone kits across various community sites, thereby increasing the availability of life-saving measures against opioid overdoses.

The significance of this collaboration lies in its potential to address the escalating opioid poisoning crisis in Canada. NARCAN® is a pure opioid antagonist that can reverse the effects of opioid overdoses within minutes, making it an essential tool for emergency response. Emergent has delivered over 100 million doses of NARCAN® across Canada and the U.S. since 2016, emphasizing its role in public health strategies aimed at mitigating opioid-related fatalities. The partnership with B.C. is expected to enhance community preparedness and empower individuals to respond effectively to overdose situations.

This development underscores a pivotal shift in public health policy and drug accessibility, particularly in the realm of opioid crisis management. By integrating nasal naloxone into the THN program, there is an opportunity to significantly improve community health outcomes and reduce mortality rates associated with opioid overdoses. This initiative may also serve as a model for other provinces and territories, potentially accelerating the timeline for similar programs across Canada and influencing future drug development strategies focused on combating the opioid epidemic.

Source: globenewswire.com