The recent discourse on intrinsic capacity (IC) in aging, initiated by the WHO, has prompted researchers to explore its measurement in animal models. While IC encompasses a range of physical and mental capacities, including motor skills, sensory function, vitality, psychological wellness, and cognition, the lack of consensus on measurement techniques has hindered progress. Despite numerous studies attempting to correlate IC with health data, the absence of standardized methodologies complicates comparisons across research efforts. The current paper seeks to refine the conversation by proposing the use of animal models to longitudinally track IC during aging, addressing the challenges inherent in human studies.

The significance of this approach lies in the potential for accelerated insights into IC dynamics. Animal models, such as mice and killifish, offer shorter lifespans that facilitate the study of aging trajectories over a compressed timeframe. This allows researchers to investigate longitudinal changes in IC and identify modifiable risk factors that contribute to its decline. By employing behavioral paradigms to assess preserved functional ability, these models can mirror the age-related changes observed in humans, thereby enhancing the understanding of IC across species. Moreover, the establishment of assessment tools that align with human IC domains could pave the way for more effective interventions in aging populations.

The takeaway from this discussion is the urgent need to prioritize longitudinal IC investigations in animal models as a means of advancing research and clinical care in aging. By operationalizing IC assessments in mice and fish, researchers can not only contribute to the foundational understanding of aging but also inform therapeutic strategies aimed at promoting healthy aging in humans. This shift in focus towards animal models may ultimately expedite the development of interventions that enhance functional ability and well-being in older adults.

Source: fightaging.org