Nicotinamide adenine dinucleotide, a coenzyme critical for cellular energy metabolism that declines with age. NAD+ precursors like NMN and NR are studied as longevity interventions.

Mechanistic target of rapamycin, a key nutrient-sensing pathway that regulates cell growth and aging. Inhibiting mTOR (e.g., with rapamycin) has shown lifespan extension in multiple organisms.

A class of drugs that selectively eliminate senescent (aged, dysfunctional) cells to reduce inflammation and improve tissue function.

What is Epigenetic clock?

A biomarker based on DNA methylation patterns that estimates biological age, often more predictive of health outcomes than chronological age.

The period of life spent in good health, free from chronic diseases and disability associated with aging.

An immunosuppressant drug that inhibits the mTOR pathway. Research shows rapamycin may extend lifespan and improve age-related health outcomes in multiple species.

What is Biological age?

A measure of how well or poorly your body is functioning relative to your chronological age, assessed through biomarkers such as DNA methylation, telomere length, and blood panels.

What is Caloric restriction?

A dietary regimen that reduces calorie intake without malnutrition. Caloric restriction is one of the most studied interventions shown to extend lifespan across species.

Protective caps at the ends of chromosomes that shorten with each cell division. Telomere length is associated with aging and age-related diseases.

A state in which cells permanently stop dividing but resist death, accumulating with age and secreting inflammatory factors that damage surrounding tissue.

A second-generation epigenetic clock that predicts time to death and is considered one of the most accurate measures of biological aging.

What is Inflammaging?

Chronic, low-grade inflammation that increases with age and contributes to the development of age-related diseases including cardiovascular disease, diabetes, and neurodegeneration.

The large-scale study of proteins in biological systems. In longevity research, proteomics identifies blood protein signatures that predict biological age and disease risk.

What is Yamanaka factors?

A set of four transcription factors (Oct4, Sox2, Klf4, c-Myc) that can reprogram adult cells to a pluripotent state. Partial reprogramming with Yamanaka factors is being explored to reverse cellular aging.

Nicotinamide mononucleotide, a precursor to NAD+ that is widely studied as a supplement to boost cellular energy and combat age-related decline.

A gene-editing technology that allows precise modifications to DNA. In longevity research, CRISPR is used to study and potentially modify genes associated with aging.

Hone Health adds DEXA scans to personalized longevity platform

Hone Health has integrated BodySpec’s clinical-grade DEXA scans into its telehealth platform, marking a significant advancement in the way body composition is assessed and monitored. This partnership aims to provide deeper insights into an individual’s health, moving beyond simple weight measurements to a nuanced understanding of muscle, fat, and bone density changes over time. By incorporating DEXA scans, Hone Health enhances its vision of a “Personalized OS for Longevity,” where various health data points—blood work, hormone levels, and now body composition—are interconnected, allowing for a comprehensive view of patient health.

The integration of DEXA scans is particularly significant as it shifts the paradigm from reactive to proactive health management. Traditionally, DEXA scans have been used primarily for osteoporosis detection in older adults, often after significant health issues have developed. By enabling earlier detection of changes in body composition, such as visceral fat accumulation and muscle loss, Hone Health empowers clinicians to adjust treatment plans more accurately and promptly. As noted by Saad Alam, CEO of Hone Health, this capability allows for a more refined approach to assessing metabolic health, which is critical for preventing long-term health complications.

The key takeaway from this development is the potential to transform clinical practice in the longevity field. The integration of DEXA scans into a connected care ecosystem not only democratizes access to high-quality body composition data but also fosters a continuous feedback loop between measurement and intervention. This shift could redefine drug development timelines and research paradigms by emphasizing the importance of early detection and intervention in aging biology. As the field moves towards more integrated and proactive health management strategies, technologies like DEXA scans will be essential in enabling clinicians to catch declines before they become significant, ultimately improving healthspan and longevity.

Source: longevity.technology