Nicotinamide adenine dinucleotide, a coenzyme critical for cellular energy metabolism that declines with age. NAD+ precursors like NMN and NR are studied as longevity interventions.

Mechanistic target of rapamycin, a key nutrient-sensing pathway that regulates cell growth and aging. Inhibiting mTOR (e.g., with rapamycin) has shown lifespan extension in multiple organisms.

A class of drugs that selectively eliminate senescent (aged, dysfunctional) cells to reduce inflammation and improve tissue function.

What is Epigenetic clock?

A biomarker based on DNA methylation patterns that estimates biological age, often more predictive of health outcomes than chronological age.

The period of life spent in good health, free from chronic diseases and disability associated with aging.

An immunosuppressant drug that inhibits the mTOR pathway. Research shows rapamycin may extend lifespan and improve age-related health outcomes in multiple species.

What is Biological age?

A measure of how well or poorly your body is functioning relative to your chronological age, assessed through biomarkers such as DNA methylation, telomere length, and blood panels.

What is Caloric restriction?

A dietary regimen that reduces calorie intake without malnutrition. Caloric restriction is one of the most studied interventions shown to extend lifespan across species.

Protective caps at the ends of chromosomes that shorten with each cell division. Telomere length is associated with aging and age-related diseases.

A state in which cells permanently stop dividing but resist death, accumulating with age and secreting inflammatory factors that damage surrounding tissue.

A second-generation epigenetic clock that predicts time to death and is considered one of the most accurate measures of biological aging.

What is Inflammaging?

Chronic, low-grade inflammation that increases with age and contributes to the development of age-related diseases including cardiovascular disease, diabetes, and neurodegeneration.

The large-scale study of proteins in biological systems. In longevity research, proteomics identifies blood protein signatures that predict biological age and disease risk.

What is Yamanaka factors?

A set of four transcription factors (Oct4, Sox2, Klf4, c-Myc) that can reprogram adult cells to a pluripotent state. Partial reprogramming with Yamanaka factors is being explored to reverse cellular aging.

Nicotinamide mononucleotide, a precursor to NAD+ that is widely studied as a supplement to boost cellular energy and combat age-related decline.

A gene-editing technology that allows precise modifications to DNA. In longevity research, CRISPR is used to study and potentially modify genes associated with aging.

AAFA Highlights New Resources for Nasal Polyps in Recognition of Global CRSwNP Awareness Day

The Asthma and Allergy Foundation of America (AAFA) has launched the Patient-Centered Education and Care for Nasal Polyps (PEACE-NP) program, coinciding with Global CRSwNP Awareness Day. This initiative aims to enhance patient understanding and management of chronic rhinosinusitis with nasal polyps (CRSwNP), a condition affecting approximately 2-3% of U.S. adults. The program includes a video series featuring expert insights on nasal polyps and a Sinus Visit Checklist designed to facilitate more productive healthcare interactions.

The significance of this initiative lies in addressing the prolonged diagnostic journey and treatment challenges faced by patients with nasal polyps. Many individuals experience difficulties in accessing effective treatments, and the recurrence of polyps post-surgery complicates care. The PEACE-NP program provides essential resources that empower patients to advocate for their health, ultimately aiming to streamline the treatment process. The initiative reflects a commitment to improving patient-provider communication, enabling patients to articulate their symptoms and treatment preferences more effectively during consultations.

The introduction of the PEACE-NP program could shift current paradigms in nasal polyp management by emphasizing patient education and engagement. By equipping patients with tools to document their health history and concerns, healthcare providers can focus on tailored treatment discussions rather than merely gathering background information. This approach not only enhances the patient experience but may also lead to improved treatment adherence and outcomes, potentially influencing future research directions and therapeutic strategies in the field of allergy and respiratory health.

Source: globenewswire.com