Nicotinamide adenine dinucleotide, a coenzyme critical for cellular energy metabolism that declines with age. NAD+ precursors like NMN and NR are studied as longevity interventions.

Mechanistic target of rapamycin, a key nutrient-sensing pathway that regulates cell growth and aging. Inhibiting mTOR (e.g., with rapamycin) has shown lifespan extension in multiple organisms.

A class of drugs that selectively eliminate senescent (aged, dysfunctional) cells to reduce inflammation and improve tissue function.

What is Epigenetic clock?

A biomarker based on DNA methylation patterns that estimates biological age, often more predictive of health outcomes than chronological age.

The period of life spent in good health, free from chronic diseases and disability associated with aging.

An immunosuppressant drug that inhibits the mTOR pathway. Research shows rapamycin may extend lifespan and improve age-related health outcomes in multiple species.

What is Biological age?

A measure of how well or poorly your body is functioning relative to your chronological age, assessed through biomarkers such as DNA methylation, telomere length, and blood panels.

What is Caloric restriction?

A dietary regimen that reduces calorie intake without malnutrition. Caloric restriction is one of the most studied interventions shown to extend lifespan across species.

Protective caps at the ends of chromosomes that shorten with each cell division. Telomere length is associated with aging and age-related diseases.

A state in which cells permanently stop dividing but resist death, accumulating with age and secreting inflammatory factors that damage surrounding tissue.

A second-generation epigenetic clock that predicts time to death and is considered one of the most accurate measures of biological aging.

What is Inflammaging?

Chronic, low-grade inflammation that increases with age and contributes to the development of age-related diseases including cardiovascular disease, diabetes, and neurodegeneration.

The large-scale study of proteins in biological systems. In longevity research, proteomics identifies blood protein signatures that predict biological age and disease risk.

What is Yamanaka factors?

A set of four transcription factors (Oct4, Sox2, Klf4, c-Myc) that can reprogram adult cells to a pluripotent state. Partial reprogramming with Yamanaka factors is being explored to reverse cellular aging.

Nicotinamide mononucleotide, a precursor to NAD+ that is widely studied as a supplement to boost cellular energy and combat age-related decline.

A gene-editing technology that allows precise modifications to DNA. In longevity research, CRISPR is used to study and potentially modify genes associated with aging.

A cellular housekeeping process where cells break down and recycle damaged components. Declines with age and is stimulated by fasting.

What is Intermittent fasting?

An eating pattern that cycles between periods of fasting and eating. Various protocols (16:8, 5:2) are studied for metabolic, cardiovascular, and longevity benefits.

What is Zone 2 cardio?

Low-intensity aerobic exercise performed at roughly 60–70% of maximum heart rate, primarily using the aerobic energy system. Associated with mitochondrial health and longevity.

Geographic regions identified by researchers where people consistently live longer and healthier lives than average, including Sardinia, Okinawa, and Loma Linda.

Can new CRISPR therapies lower your cholesterol safely?

Scribe Therapeutics has announced its upcoming presentations at two major conferences, showcasing advancements in CRISPR technology that could have significant implications for heart and metabolic health. At the ASGCT Annual Meeting in May, the company will highlight its innovative Epigenetic Long-Term X-Repressor (ELXR) and X-Editor (XE) technologies, along with its AI-enabled CRISPR design platform, DeepXE. These advancements aim to improve the precision and effectiveness of CRISPR systems, which could lead to more targeted therapies for various health conditions.

This research is particularly relevant for individuals concerned about heart health and cholesterol levels. Scribe’s late-breaking data on STX-1150, a liver-targeted therapy, suggests it can effectively lower LDL cholesterol (LDL-C) after just one dose, without causing permanent changes to DNA. This could be a game-changer for people looking to manage their cholesterol levels safely and effectively, potentially reducing the risk of heart disease.

The findings presented by Scribe are based on early-stage research and preclinical data, meaning they are promising but not yet proven in large human trials. While the results are encouraging, it’s essential to approach them with caution until more extensive studies validate these findings in humans.

For now, staying informed about developments in CRISPR and other innovative therapies can empower you to make better health decisions. If you’re concerned about cholesterol or heart health, consider discussing your options with a healthcare professional who can provide personalized advice based on the latest research.

Source: longevity.technology