Nicotinamide adenine dinucleotide, a coenzyme critical for cellular energy metabolism that declines with age. NAD+ precursors like NMN and NR are studied as longevity interventions.

Mechanistic target of rapamycin, a key nutrient-sensing pathway that regulates cell growth and aging. Inhibiting mTOR (e.g., with rapamycin) has shown lifespan extension in multiple organisms.

A class of drugs that selectively eliminate senescent (aged, dysfunctional) cells to reduce inflammation and improve tissue function.

What is Epigenetic clock?

A biomarker based on DNA methylation patterns that estimates biological age, often more predictive of health outcomes than chronological age.

The period of life spent in good health, free from chronic diseases and disability associated with aging.

An immunosuppressant drug that inhibits the mTOR pathway. Research shows rapamycin may extend lifespan and improve age-related health outcomes in multiple species.

What is Biological age?

A measure of how well or poorly your body is functioning relative to your chronological age, assessed through biomarkers such as DNA methylation, telomere length, and blood panels.

What is Caloric restriction?

A dietary regimen that reduces calorie intake without malnutrition. Caloric restriction is one of the most studied interventions shown to extend lifespan across species.

Protective caps at the ends of chromosomes that shorten with each cell division. Telomere length is associated with aging and age-related diseases.

A state in which cells permanently stop dividing but resist death, accumulating with age and secreting inflammatory factors that damage surrounding tissue.

A second-generation epigenetic clock that predicts time to death and is considered one of the most accurate measures of biological aging.

What is Inflammaging?

Chronic, low-grade inflammation that increases with age and contributes to the development of age-related diseases including cardiovascular disease, diabetes, and neurodegeneration.

The large-scale study of proteins in biological systems. In longevity research, proteomics identifies blood protein signatures that predict biological age and disease risk.

What is Yamanaka factors?

A set of four transcription factors (Oct4, Sox2, Klf4, c-Myc) that can reprogram adult cells to a pluripotent state. Partial reprogramming with Yamanaka factors is being explored to reverse cellular aging.

Nicotinamide mononucleotide, a precursor to NAD+ that is widely studied as a supplement to boost cellular energy and combat age-related decline.

A gene-editing technology that allows precise modifications to DNA. In longevity research, CRISPR is used to study and potentially modify genes associated with aging.

A cellular housekeeping process where cells break down and recycle damaged components. Declines with age and is stimulated by fasting.

What is Intermittent fasting?

An eating pattern that cycles between periods of fasting and eating. Various protocols (16:8, 5:2) are studied for metabolic, cardiovascular, and longevity benefits.

What is Zone 2 cardio?

Low-intensity aerobic exercise performed at roughly 60–70% of maximum heart rate, primarily using the aerobic energy system. Associated with mitochondrial health and longevity.

Geographic regions identified by researchers where people consistently live longer and healthier lives than average, including Sardinia, Okinawa, and Loma Linda.

Join the Tunnel to Towers 5K and Honor Heroes

Registration is now open for the 25th Tunnel to Towers 5K Run & Walk in New York City, set for September 27, 2026. This event honors the memory of first responders and civilians lost on September 11, 2001, and aims to bring together tens of thousands of participants, including runners, walkers, veterans, and first responders. The race will retrace the final footsteps of FDNY Firefighter Stephen Siller, who heroically ran through the Brooklyn-Battery Tunnel on that tragic day to save lives. With a cap of 30,000 participants, this milestone event promises a meaningful experience as it commemorates the sacrifices made by many.

For those looking to support a good cause while staying active, participating in the Tunnel to Towers 5K is a great opportunity. The event not only promotes physical fitness but also raises awareness and funds for the Tunnel to Towers Foundation, which has provided over 2,000 mortgage-free homes to catastrophically injured veterans, first responders, and families of fallen heroes. By joining this event, you can contribute to a mission that helps ensure that the sacrifices of those who served are never forgotten.

The Tunnel to Towers Foundation has been making a significant impact since its inception, committing over $1 billion to various programs aimed at helping military members and first responders. Their efforts also include offering scholarships for the children of home recipients, ensuring a brighter future for the next generation. By participating in the 5K, you can help support these initiatives while honoring the legacy of those who made the ultimate sacrifice.

Source: globenewswire.com