Nicotinamide adenine dinucleotide, a coenzyme critical for cellular energy metabolism that declines with age. NAD+ precursors like NMN and NR are studied as longevity interventions.

Mechanistic target of rapamycin, a key nutrient-sensing pathway that regulates cell growth and aging. Inhibiting mTOR (e.g., with rapamycin) has shown lifespan extension in multiple organisms.

A class of drugs that selectively eliminate senescent (aged, dysfunctional) cells to reduce inflammation and improve tissue function.

What is Epigenetic clock?

A biomarker based on DNA methylation patterns that estimates biological age, often more predictive of health outcomes than chronological age.

The period of life spent in good health, free from chronic diseases and disability associated with aging.

An immunosuppressant drug that inhibits the mTOR pathway. Research shows rapamycin may extend lifespan and improve age-related health outcomes in multiple species.

What is Biological age?

A measure of how well or poorly your body is functioning relative to your chronological age, assessed through biomarkers such as DNA methylation, telomere length, and blood panels.

What is Caloric restriction?

A dietary regimen that reduces calorie intake without malnutrition. Caloric restriction is one of the most studied interventions shown to extend lifespan across species.

Protective caps at the ends of chromosomes that shorten with each cell division. Telomere length is associated with aging and age-related diseases.

A state in which cells permanently stop dividing but resist death, accumulating with age and secreting inflammatory factors that damage surrounding tissue.

A second-generation epigenetic clock that predicts time to death and is considered one of the most accurate measures of biological aging.

What is Inflammaging?

Chronic, low-grade inflammation that increases with age and contributes to the development of age-related diseases including cardiovascular disease, diabetes, and neurodegeneration.

The large-scale study of proteins in biological systems. In longevity research, proteomics identifies blood protein signatures that predict biological age and disease risk.

What is Yamanaka factors?

A set of four transcription factors (Oct4, Sox2, Klf4, c-Myc) that can reprogram adult cells to a pluripotent state. Partial reprogramming with Yamanaka factors is being explored to reverse cellular aging.

Nicotinamide mononucleotide, a precursor to NAD+ that is widely studied as a supplement to boost cellular energy and combat age-related decline.

A gene-editing technology that allows precise modifications to DNA. In longevity research, CRISPR is used to study and potentially modify genes associated with aging.

A cellular housekeeping process where cells break down and recycle damaged components. Declines with age and is stimulated by fasting.

What is Intermittent fasting?

An eating pattern that cycles between periods of fasting and eating. Various protocols (16:8, 5:2) are studied for metabolic, cardiovascular, and longevity benefits.

What is Zone 2 cardio?

Low-intensity aerobic exercise performed at roughly 60–70% of maximum heart rate, primarily using the aerobic energy system. Associated with mitochondrial health and longevity.

Geographic regions identified by researchers where people consistently live longer and healthier lives than average, including Sardinia, Okinawa, and Loma Linda.

Can a wearable device help manage hand tremors?

Cala Health has received a significant boost with a $50 million investment from Trinity Capital to expand its operations and enhance its innovative wearable therapy for tremors. The Cala kIQ System is a wrist-worn device that measures tremor patterns and delivers personalized nerve stimulation to help manage hand tremors associated with essential tremor and Parkinson’s disease. This FDA-cleared device is designed for at-home use, making it a convenient option for people looking to alleviate their symptoms.

For those dealing with hand tremors, this development could mean a new way to regain control over daily tasks. The Cala kIQ System aims to provide temporary relief from tremors, allowing users to perform activities with greater ease and confidence. This could be particularly beneficial for older adults or anyone experiencing the challenges of tremor-related conditions, as it offers a non-invasive solution that can be used in the comfort of home.

The investment from Trinity Capital is aimed at scaling Cala Health’s U.S. operations and improving patient access to this unique therapy. While the Cala kIQ System is FDA-cleared, it’s important to note that this is not a cure for tremors but rather a management tool. The effectiveness of the device is based on individual experiences, and further research may continue to refine its capabilities and benefits for users.

If you or someone you know struggles with hand tremors, exploring options like the Cala kIQ System could be a step toward improving quality of life. Always consult with a healthcare provider to discuss the best treatment options for your specific needs.

Source: longevity.technology