Nicotinamide adenine dinucleotide, a coenzyme critical for cellular energy metabolism that declines with age. NAD+ precursors like NMN and NR are studied as longevity interventions.

Mechanistic target of rapamycin, a key nutrient-sensing pathway that regulates cell growth and aging. Inhibiting mTOR (e.g., with rapamycin) has shown lifespan extension in multiple organisms.

A class of drugs that selectively eliminate senescent (aged, dysfunctional) cells to reduce inflammation and improve tissue function.

What is Epigenetic clock?

A biomarker based on DNA methylation patterns that estimates biological age, often more predictive of health outcomes than chronological age.

The period of life spent in good health, free from chronic diseases and disability associated with aging.

An immunosuppressant drug that inhibits the mTOR pathway. Research shows rapamycin may extend lifespan and improve age-related health outcomes in multiple species.

What is Biological age?

A measure of how well or poorly your body is functioning relative to your chronological age, assessed through biomarkers such as DNA methylation, telomere length, and blood panels.

What is Caloric restriction?

A dietary regimen that reduces calorie intake without malnutrition. Caloric restriction is one of the most studied interventions shown to extend lifespan across species.

Protective caps at the ends of chromosomes that shorten with each cell division. Telomere length is associated with aging and age-related diseases.

A state in which cells permanently stop dividing but resist death, accumulating with age and secreting inflammatory factors that damage surrounding tissue.

A second-generation epigenetic clock that predicts time to death and is considered one of the most accurate measures of biological aging.

What is Inflammaging?

Chronic, low-grade inflammation that increases with age and contributes to the development of age-related diseases including cardiovascular disease, diabetes, and neurodegeneration.

The large-scale study of proteins in biological systems. In longevity research, proteomics identifies blood protein signatures that predict biological age and disease risk.

What is Yamanaka factors?

A set of four transcription factors (Oct4, Sox2, Klf4, c-Myc) that can reprogram adult cells to a pluripotent state. Partial reprogramming with Yamanaka factors is being explored to reverse cellular aging.

Nicotinamide mononucleotide, a precursor to NAD+ that is widely studied as a supplement to boost cellular energy and combat age-related decline.

A gene-editing technology that allows precise modifications to DNA. In longevity research, CRISPR is used to study and potentially modify genes associated with aging.

A cellular housekeeping process where cells break down and recycle damaged components. Declines with age and is stimulated by fasting.

What is Intermittent fasting?

An eating pattern that cycles between periods of fasting and eating. Various protocols (16:8, 5:2) are studied for metabolic, cardiovascular, and longevity benefits.

What is Zone 2 cardio?

Low-intensity aerobic exercise performed at roughly 60–70% of maximum heart rate, primarily using the aerobic energy system. Associated with mitochondrial health and longevity.

Geographic regions identified by researchers where people consistently live longer and healthier lives than average, including Sardinia, Okinawa, and Loma Linda.

What new treatments are coming for healthy aging?

MBX Biosciences, Inc. will present at the Jefferies 2026 Global Healthcare Conference, showcasing their latest advancements in precision peptide therapies aimed at treating endocrine and metabolic disorders. This presentation will feature insights from CEO Kent Hawryluk and Chief Medical Officer Sam Azoulay, and it is scheduled for June 3, 2026. For those interested, a live webcast will be available on the company’s website, with a replay accessible shortly after.

This matters for anyone interested in healthy aging because MBX is developing therapies that could address common health issues like chronic hypoparathyroidism and obesity. These conditions can significantly impact your well-being as you age, affecting your hormone levels, metabolism, and overall health. If successful, MBX’s treatments may help improve your energy levels and metabolic health, potentially leading to a better quality of life.

The research is still in the early stages, with some therapies in clinical trials and others in preclinical development. For instance, canvuparatide (MBX 2109) is preparing for Phase 3 trials, which is a critical step before any potential approval for public use. While the company has promising candidates in its pipeline, it’s important to remember that these treatments are not yet available and require further testing to confirm their safety and effectiveness.

If you’re curious about these developments, staying informed about MBX and similar companies may be beneficial. While waiting for new treatments, focus on maintaining a healthy lifestyle through balanced nutrition, regular exercise, and routine health check-ups to support your well-being as you age.

Source: longevity.technology