Nicotinamide adenine dinucleotide, a coenzyme critical for cellular energy metabolism that declines with age. NAD+ precursors like NMN and NR are studied as longevity interventions.

Mechanistic target of rapamycin, a key nutrient-sensing pathway that regulates cell growth and aging. Inhibiting mTOR (e.g., with rapamycin) has shown lifespan extension in multiple organisms.

A class of drugs that selectively eliminate senescent (aged, dysfunctional) cells to reduce inflammation and improve tissue function.

What is Epigenetic clock?

A biomarker based on DNA methylation patterns that estimates biological age, often more predictive of health outcomes than chronological age.

The period of life spent in good health, free from chronic diseases and disability associated with aging.

An immunosuppressant drug that inhibits the mTOR pathway. Research shows rapamycin may extend lifespan and improve age-related health outcomes in multiple species.

What is Biological age?

A measure of how well or poorly your body is functioning relative to your chronological age, assessed through biomarkers such as DNA methylation, telomere length, and blood panels.

What is Caloric restriction?

A dietary regimen that reduces calorie intake without malnutrition. Caloric restriction is one of the most studied interventions shown to extend lifespan across species.

Protective caps at the ends of chromosomes that shorten with each cell division. Telomere length is associated with aging and age-related diseases.

A state in which cells permanently stop dividing but resist death, accumulating with age and secreting inflammatory factors that damage surrounding tissue.

A second-generation epigenetic clock that predicts time to death and is considered one of the most accurate measures of biological aging.

What is Inflammaging?

Chronic, low-grade inflammation that increases with age and contributes to the development of age-related diseases including cardiovascular disease, diabetes, and neurodegeneration.

The large-scale study of proteins in biological systems. In longevity research, proteomics identifies blood protein signatures that predict biological age and disease risk.

What is Yamanaka factors?

A set of four transcription factors (Oct4, Sox2, Klf4, c-Myc) that can reprogram adult cells to a pluripotent state. Partial reprogramming with Yamanaka factors is being explored to reverse cellular aging.

Nicotinamide mononucleotide, a precursor to NAD+ that is widely studied as a supplement to boost cellular energy and combat age-related decline.

A gene-editing technology that allows precise modifications to DNA. In longevity research, CRISPR is used to study and potentially modify genes associated with aging.

A cellular housekeeping process where cells break down and recycle damaged components. Declines with age and is stimulated by fasting.

What is Intermittent fasting?

An eating pattern that cycles between periods of fasting and eating. Various protocols (16:8, 5:2) are studied for metabolic, cardiovascular, and longevity benefits.

What is Zone 2 cardio?

Low-intensity aerobic exercise performed at roughly 60–70% of maximum heart rate, primarily using the aerobic energy system. Associated with mitochondrial health and longevity.

Geographic regions identified by researchers where people consistently live longer and healthier lives than average, including Sardinia, Okinawa, and Loma Linda.

How to Manage Pain Safely as You Age

Researchers found that older adults are facing a growing crisis with opioid dependency, prompting a new summit in New Jersey aimed at addressing this issue. The 2nd Annual NJ Healthy Aging Summit on Opioid Safety & Alternatives will take place on June 5, 2026, at the Golden Nugget Hotel & Casino. Organized by the Partnership for a Drug-Free New Jersey, the summit will focus on the risks associated with prescription opioid use and will promote safer, evidence-based alternatives for managing pain.

This event is particularly relevant for older adults who often deal with chronic pain and multiple prescriptions, which can increase the risk of opioid misuse. The summit aims to empower attendees with knowledge about safer pain management strategies, including exercise, nutrition, and mental wellness. By providing practical solutions and community resources, the summit seeks to help older residents maintain their strength, balance, and overall well-being, ultimately supporting healthier aging.

The summit will feature expert speakers who will discuss the opioid epidemic and present guidelines for the safe use and disposal of medications. While the event is a significant step towards addressing opioid safety, it is important to note that this is an early-stage initiative. The information shared will be based on current trends and research, but ongoing efforts will be needed to combat the rising rates of opioid-related issues among older adults.

If you are an older adult or know someone who is, consider attending the summit to learn about safer alternatives to pain management and to connect with resources that support healthy aging. For more details and registration, visit NJHealthyAging.org.

Source: globenewswire.com