Researchers found that the timing of your menstrual cycle may influence how you respond to COVID-19 vaccinations. A study from the London School of Hygiene & Tropical Medicine and the University of Montpellier, using data from the Clue menstrual tracking app, revealed that individuals vaccinated during the follicular phase—when estrogen is dominant—reported 35% more side effects than those vaccinated during the luteal phase, when progesterone is more prevalent. Interestingly, those vaccinated in the follicular phase also experienced a longer median time before a subsequent COVID-19 infection, although this finding is still exploratory.

This research is significant for anyone interested in optimizing their health and wellness. If you’re a woman or someone who menstruates, understanding how your cycle might affect vaccine responses could help you make informed decisions about your health. While the study does not suggest timing your vaccination around your menstrual cycle, it highlights the need to consider menstrual health in broader health contexts. The findings suggest that hormonal fluctuations could play a role in immune responses, which could be crucial for future vaccine strategies.

The evidence comes from a study involving 1,474 Clue users who provided detailed cycle data and vaccination experiences. While this study is a pioneering effort in linking menstrual cycle phases with vaccine responses, it is still in the early stages. Researchers caution against making any immediate changes to vaccination timing based on these results, emphasizing that getting vaccinated when eligible is far more critical than the timing within your cycle.

For those interested in this topic, it may be beneficial to track your menstrual cycle and discuss any concerns with your healthcare provider, particularly regarding vaccinations and overall health.

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