Researchers found that women who used estrogen-only hormone therapy later in life had significantly lower chances of developing dementia and exhibited fewer signs of Alzheimer’s disease in their brains. A large study involving over 21,000 women revealed that hormone therapy was linked to a 39% reduction in dementia diagnoses and a 35% decrease in Alzheimer’s-related brain changes, such as amyloid plaques and tau tangles. These findings suggest that hormone therapy could play a role in maintaining brain health as women age.

This research is particularly relevant for women seeking to age well and preserve cognitive function. The study indicates that those who used hormone therapy were less likely to experience memory issues or declines in daily living skills. Among participants who underwent autopsies, 18% of hormone therapy users showed no signs of Alzheimer’s, compared to only 10% of those who did not use the therapy. This suggests that estrogen may have protective effects on the brain, potentially benefiting women in their later years.

However, it’s important to note that this study is observational and does not establish a direct cause-and-effect relationship. The participants primarily began hormone therapy after age 70, which differs from current practices that typically recommend starting treatment in the late 40s to early 50s. Therefore, while the findings are promising, they should be interpreted with caution, and further research is needed to understand the implications for today’s hormone therapy protocols.

For women considering hormone therapy, it’s essential to consult with healthcare professionals to weigh the benefits and risks based on individual health needs and current medical guidelines.

Source: American Academy of Neurology