Researchers have found that a protein called ANGPTL8, produced by aging fat cells, is linked to increased inflammation and higher risks of age-related diseases and mortality. This protein circulates in the blood and has been shown to negatively impact health outcomes in both humans and mice. In particular, higher levels of ANGPTL8 are associated with serious conditions like diabetes and cardiovascular diseases, making it a significant marker for health as we age.

For those looking to age well, understanding ANGPTL8 could be crucial. The research indicates that as this protein accumulates, it may lead to worse health outcomes, including increased biological age and a higher likelihood of dying within a decade. The study involved nearly 10,000 participants and found that keeping ANGPTL8 levels around 250 nanograms per liter of serum could be beneficial for maintaining a healthier biological age. Mice that do not produce ANGPTL8 showed improved physical performance and longer lifespans, suggesting that lowering ANGPTL8 could enhance health and longevity.

The evidence comes from a combination of human cohort studies and mouse models, providing a solid foundation for these findings. While the research is promising, it’s still in the early stages, and more work is needed to explore how to effectively manage ANGPTL8 levels in humans. Researchers are optimistic about the potential for developing treatments that target this protein, which could lead to longer, healthier lives for those dealing with metabolic issues.

Source: lifespan.io